ResearchIn-Press PreviewCell biologyNeuroscience
Open Access | 
10.1172/jci.insight.192155
Sex specific disruptions in PKCγ signaling in a mouse model of Spinocerebellar Ataxia Type 14
Sarah A. Wolfe,1 Yuliang Ma,1 Tomer M. Yaron-Barir,2 Carly Chang,1 Caila A. Pilo,1 Majid Ghassemian,3 Amanda J. Roberts,4 Sang Ryeul Lee,5 Benjamin A. Henson,6 Kristen Jepsen,6 Jared L. Johnson,2 Lewis C. Cantley,2 Susan S. Taylor,1 George Gorrie,7 and Alexandra C. Newton1
1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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Roberts, A.
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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Johnson, J.
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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1Department of Pharmacology, University of California, San Diego, La Jolla, United States of America
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States of America
3Department of Chemistry and Biochemistry, Biomolecular and Proteomics Mass Spectrometry Facility, University of California, San Diego, La Jolla, United States of America
4Animal Models Core Facility, The Scripps Research Institute, La Jolla, United States of America
5The UCSD Transgenic Mouse Core, University of California, San Diego, La Jolla, United States of America
6Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States of America
7Queen Elizabeth University Hospital, Glasgow, United Kingdom
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Published April 2, 2026 - More info
Copyright © 2026, Wolfe et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
