ResearchIn-Press PreviewCell biologyNeuroscience
Open Access | 
10.1172/jci.insight.198224
Norepinephrinergic projection from locus coeruleus to parafascicular nucleus promotes pain and anxiety-like behaviors in mice
Zhong-Yi Liu,1 Fei Li,1 Li-Ming Liu,1 Yao-Hua Liu,1 Jia Li,1 Zi-Ang Li,1 Jin Cheng,1 Tian-Yu Zhao,1 Hui-Min Tian,1 Dong-Ning Li,1 Sha-Sha Tao,1 Hui Li,1 Fen-Sheng Huang,2 and Yun-Qing Li1
1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
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1Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, China
2Institute of Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
Find articles by Li, Y. in: PubMed | Google Scholar
Published April 7, 2026 - More info
Copyright © 2026, Liu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
