ResearchIn-Press PreviewImmunologyInfectious disease
Open Access | 
10.1172/jci.insight.198461
Natural killer cells from children with obesity exhibit a persistent ‘trained’ response to influenza
Ellesandra C. Noye,1 Megan Airey,1 Danielle K. Longmore,2 Hui Xu,3 David Chisanga,3 Christoph Saner,2 Meagan Carney,4 Meg Kaegi,2 Hiu On Man,5 M. Zeeshan Chaudhry,5 Liam C. Kealy,3 Julian D. J. Sng,1 Isabelle Hocking,1 Melanie Wu,1 Georgina McCallum,1 Gabrielle T. Belz,5 Kim L. Good-Jacobson,3 David Burgner,2 Siroon Bekkering,2 and Kirsty Short1
1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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Xu, H.
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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Kealy, L.
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
2Murdoch Children's Research Institute, Royal Children’s Hospital, Melbourne, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
4School of Mathematics and Physics, The University of Queensland, Brisbane, Australia
5Frazer Institute, The University of Queensland, Brisbane, Australia
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Published November 3, 2026 - More info
Copyright © 2026, Noye et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
