Periostin defines a pathological fibroblast program enriched in restrictive allograft syndrome
Yudai Miyashita, Taisuke Kaiho, Yuriko Yagi, Taichi Nagano, Xin Wu, Yuanqing Yan, Haiying Sun, Carl Atkinson, GR Scott Budinger, Ankit Bharat, Chitaru Kurihara
Yudai Miyashita, Taisuke Kaiho, Yuriko Yagi, Taichi Nagano, Xin Wu, Yuanqing Yan, Haiying Sun, Carl Atkinson, GR Scott Budinger, Ankit Bharat, Chitaru Kurihara
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Research Letter Immunology Pulmonology

Periostin defines a pathological fibroblast program enriched in restrictive allograft syndrome

Abstract

Authors

Yudai Miyashita, Taisuke Kaiho, Yuriko Yagi, Taichi Nagano, Xin Wu, Yuanqing Yan, Haiying Sun, Carl Atkinson, GR Scott Budinger, Ankit Bharat, Chitaru Kurihara

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Figure 1

POSTN marks a pathological fibroblast program enriched in RAS.

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POSTN marks a pathological fibroblast program enriched in RAS. (A) Study...
(A) Study design. (B) UMAP of 4 fibroblast states. (C and D) Fibroblast state proportions by phenotype and individual lobar samples. (E) Differential expression in fibroblasts (RAS vs. BOS). (F) Single-cell POSTN expression in fibroblasts. (G) Sample-level POSTN abundance. (H) Representative H&E, trichrome, and POSTN immunostaining. (I) Histologic scoring and POSTN-positive area fraction. The Kruskal-Wallis test followed by Dunn’s multiple-comparison test was used. Box-and-whisker plots show the median (center line), the interquartile range (box), and whiskers extending to 1.5× the interquartile range; individual points represent lobar specimens.