ResearchIn-Press PreviewCardiologyPulmonologyVascular biology
Open Access | 
10.1172/jci.insight.200684
Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure
Jennie Vu,1 Pavel Zhabyeyev,2 Kemar J. Brown,3 Joshua M. Gorham,3 Daniel M. DeLaughter,3 Huachen Chen,2 Thilina U. Jayawardena,2 Ander Vergara,2 Maria Alexiou,4 Anjalee Wijewardane,5 Conrad Fischer,5 Charlotte Avet,6 Abby Ewasiuk,2 Faqi Wang,2 Mark C. Chappell,7 Yuri Kim,8 Michel Bouvier,6 John C. Vederas,5 Christine E. Seidman,8 Jonathan G. Seidman,3 and Gavin Y. Oudit2
1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Brown, K.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Gorham, J.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Kim, Y.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Bouvier, M.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Seidman, C.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Seidman, J.
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1Department of Physiology, University of Alberta, Edmonton, Canada
2Department of Medicine, University of Alberta, Edmonton, Canada
3Department of Genetics, Harvard Medical School, Boston, United States of America
4Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Canada
5Department of Chemistry, University of Alberta, Edmonton, Canada
6Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada
7Department of Surgery/Hypertension and Vascular Research, Wake Forest University School of Medicine, Winston Salem, United States of America
8Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America
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Oudit, G.
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Published June 18, 2026 - More info
Copyright © 2026, Vu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
