Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine
Purpose Conventional radiation treatment (20-40 Gy in 5-20 fractions, 2-5 Gy per fraction)
for sarcoma metastatic to the spine provides subtherapeutic doses, resulting in poor durable
local control (LC)(50%-77% at 1 year). Hypofractionated (HF) and/or single-fraction (SF)
image-guided stereotactic radiosurgery (IG-SRS) may provide a more effective means of
managing these lesions. Methods and Materials Patients with pathologically proven high-
grade sarcoma metastatic to the spine treated with HF and SF IG-SRS were included. LC …
for sarcoma metastatic to the spine provides subtherapeutic doses, resulting in poor durable
local control (LC)(50%-77% at 1 year). Hypofractionated (HF) and/or single-fraction (SF)
image-guided stereotactic radiosurgery (IG-SRS) may provide a more effective means of
managing these lesions. Methods and Materials Patients with pathologically proven high-
grade sarcoma metastatic to the spine treated with HF and SF IG-SRS were included. LC …
