[HTML][HTML] Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cδ/Ras/MEKK1/MKK1-dependent …
H Vuong, T Patterson, P Shapiro… - Journal of Biological …, 2000 - ASBMB
The transcriptional induction ofSPRR1B by phorbol 12-myristate 13-acetate (PMA) is mainly
mediated by the first-152-base pair 5′-flanking region containing two functional AP-1 sites.
In this study, we have analyzed the signaling pathways that mediate the induction in
tracheobronchial epithelial cells. PKC inhibitor ablated PMA-stimulated expression of
endogenousSPRR1B and reporter gene expression driven bySPRR1B promoter. PKC
activator promoted the transcription. The dominant negative protein kinase Cδ (dn-PKCδ) …
mediated by the first-152-base pair 5′-flanking region containing two functional AP-1 sites.
In this study, we have analyzed the signaling pathways that mediate the induction in
tracheobronchial epithelial cells. PKC inhibitor ablated PMA-stimulated expression of
endogenousSPRR1B and reporter gene expression driven bySPRR1B promoter. PKC
activator promoted the transcription. The dominant negative protein kinase Cδ (dn-PKCδ) …
