[HTML][HTML] Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON

CT Sun, WY Lo, IH Wang, YH Lo, SR Shiou… - Journal of Biological …, 2001 - ASBMB
A negative regulatory element (NRE) is located immediately upstream of the upstream
regulatory sequence of core promoter and second enhancer of human hepatitis B virus
(HBV). NRE represses the transcription activation function of the upstream regulatory
sequence of core promoter and the second enhancer. In this study, we described the cloning
and characterization of an NRE-binding protein (NREBP) through expression cloning.
NREBP cDNA is 8266 nucleotides in size and encodes a protein of 2386 amino acids with a …