Regulation of spinal substance p release by intrathecal calcium channel blockade
T Takasusuki, TL Yaksh - The Journal of the American Society of …, 2011 - pubs.asahq.org
Background The authors investigated the role of different voltage-sensitive calcium channels
expressed at presynaptic afferent terminals in substance P release and on nociceptive
behavior evoked by intraplantar formalin by examining the effects of intrathecally delivered
N-(ziconotide), T-(mibefradil), and L-type voltage-sensitive calcium channel blockers
(diltiazem and verapamil). Methods Rats received intrathecal pretreatment with saline or
doses of morphine, ziconotide, mibefradil, diltiazem, or verapamil. The effect of these …
expressed at presynaptic afferent terminals in substance P release and on nociceptive
behavior evoked by intraplantar formalin by examining the effects of intrathecally delivered
N-(ziconotide), T-(mibefradil), and L-type voltage-sensitive calcium channel blockers
(diltiazem and verapamil). Methods Rats received intrathecal pretreatment with saline or
doses of morphine, ziconotide, mibefradil, diltiazem, or verapamil. The effect of these …
