Energetic metabolism comprises a series of interconnected biochemical pathways capable of using energy-rich molecules to produce ATP. Cells can produce ATP either by oxidative phosphorylation (OXPHOS) or by performing glycolysis. Aerobic glycolysis supports not only proliferation but also cell survival in hypoxic conditions. Immune cells are specially equipped to migrate into peripheral tissues and to adapt to the change in microenvironment. Their energetic metabolism profile is known to correlate with their microanatomical localization, activation, proliferation, or functional state (O’Sullivan et al., 2019; Russell et al., 2019). Activation of T cells is generally linked to a metabolic switch from OXPHOS to aerobic glycolysis (Pearce et al., 2009; Roos and Loos, 1973; Warburg et al., 1958; Wieman et al., 2007). Competition for glucose within the tumor microenvironment influences cancer progression and the anti-tumoral immune response by regulating metabolism and function in both tumoral cells and tumor-infiltrating lymphocytes (TILs)(Chang et al.,