AOM/DSS model of colitis-associated cancer
B Parang, CW Barrett, CS Williams - Gastrointestinal Physiology and …, 2016 - Springer
B Parang, CW Barrett, CS Williams
Gastrointestinal Physiology and Diseases: Methods and Protocols, 2016•SpringerOur understanding of colitis-associated carcinoma (CAC) has benefited substantially from
mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have
enabled fast and efficient analysis of genetic and environmental modulators of CAC without
the added requirement of time-intensive genetic crossings. Here we describe the
Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory
colorectal cancer.
mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have
enabled fast and efficient analysis of genetic and environmental modulators of CAC without
the added requirement of time-intensive genetic crossings. Here we describe the
Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory
colorectal cancer.
Abstract
Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.
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