A novel operant method to test acute heat hypersensitivity in mice using a modification of the Coy Operant Mechanical Conflict Avoidance System

S Carlton, S Zhou - The Journal of Pain, 2013 - jpain.org
Mirror-image pain is the pain phenomenon being recognized at contralateral symmetrical
area from original injured region. The pain sensation from the contralateral side is
qualitatively similar to the original pain, but less prominent. Bilateral effects of unilateral
injury are very common phenomena in chronic pain patients and experimental animal pain
models. However, our knowledge of the mechanisms underlying such spreading of pain is
currently very limited due to reliable animal model of chronic mirror-image pain. Targeted at …