Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas
L Kluwe, RE Friedrich, VF Mautner - Cancer genetics and cytogenetics, 1999 - Elsevier
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder with a complex variety of
clinical symptoms. Genetic alteration of the NF1 gene on 17q11. 2 is the cause of this
disease. Neurofibromas of the peripheral nervous system are one main manifestation. A
variant of neurofibroma is the plexiform neurofibroma which can be found in about 30% of
NF1-patients, often causing severe clinical symptoms. In this study, we examined 14 such
tumors from 10 NF1-patients for allele loss of the NF1 gene (LOH: loss of heterozygosity) …
clinical symptoms. Genetic alteration of the NF1 gene on 17q11. 2 is the cause of this
disease. Neurofibromas of the peripheral nervous system are one main manifestation. A
variant of neurofibroma is the plexiform neurofibroma which can be found in about 30% of
NF1-patients, often causing severe clinical symptoms. In this study, we examined 14 such
tumors from 10 NF1-patients for allele loss of the NF1 gene (LOH: loss of heterozygosity) …
