[HTML][HTML] Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature
DT Dugger, M Fung, SR Hays, JP Singer… - American Journal of …, 2021 - Elsevier
Chronic lung allograft dysfunction (CLAD) is the major barrier to long-term survival following
lung transplantation, and new mechanistic biomarkers are needed. Lymphocytic bronchitis
(LB) precedes CLAD and has a defined molecular signature. We hypothesized that this LB
molecular signature would be associated with CLAD in small airway brushings independent
of infection. We quantified RNA expression from small airway brushings and transbronchial
biopsies, using RNAseq and digital RNA counting, respectively, for 22 CLAD cases and 27 …
lung transplantation, and new mechanistic biomarkers are needed. Lymphocytic bronchitis
(LB) precedes CLAD and has a defined molecular signature. We hypothesized that this LB
molecular signature would be associated with CLAD in small airway brushings independent
of infection. We quantified RNA expression from small airway brushings and transbronchial
biopsies, using RNAseq and digital RNA counting, respectively, for 22 CLAD cases and 27 …
