[HTML][HTML] Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco (endo) plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump
LH Liu, GP Boivin, V Prasad, M Periasamy… - Journal of Biological …, 2001 - ASBMB
Mutations in the human ATP2A2gene, encoding sarco (endo) plasmic reticulum Ca 2+-
ATPase isoform 2 (SERCA2), cause Darier disease, an autosomal dominant skin disease
characterized by multiple keratotic papules in the seborrheic regions of the body. Mice with a
single functional Atp2a2allele (the mouse homolog of ATP2A2) were shown previously to
have reduced levels of SERCA2 in heart and mildly impaired cardiac contractility and
relaxation. Here we show that aged heterozygous mutant (Atp2a2+/−) mice develop …
ATPase isoform 2 (SERCA2), cause Darier disease, an autosomal dominant skin disease
characterized by multiple keratotic papules in the seborrheic regions of the body. Mice with a
single functional Atp2a2allele (the mouse homolog of ATP2A2) were shown previously to
have reduced levels of SERCA2 in heart and mildly impaired cardiac contractility and
relaxation. Here we show that aged heterozygous mutant (Atp2a2+/−) mice develop …
