Helicobacter pylori eradication shifts monocyte Fcγ receptor balance toward inhibitory FcγRIIB in immune thrombocytopenic purpura patients
J. Clin. Invest. Atsuko Asahi, et al. 118:2939 doi:10.1172/JCI34496 [
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Figure 5Serial measurements of the phenotype of circulating monocytes and the anti-CagA Ab level before and after initiation of the
H. pylori eradication regimen in 9 non-ITP individuals infected with
H. pylori according to the outcome of the regimen.
Expression levels of FcγRI, FcγRII (FcγRIIA plus FcγRIIB), and CD86, non-specific phagocytosis of circulating monocytes, and anti-CagA Ab level were measured prior to treatment and 12 wk after initiation of the
H. pylori eradication regimen. Expression of FcγRII was examined using mAb clone FLI8.26, which reacts with both FcγRIIA and FcγRIIB. Results for 7 individuals in which
H. pylori was successfully eradicated and for 2 individuals in whom the eradication failed are shown separately. A dotted line indicates the cut-off for anti-CagA Abs (7.5 U).
