Helicobacter pylori eradication shifts monocyte Fcγ receptor balance toward inhibitory FcγRIIB in immune thrombocytopenic purpura patients
J. Clin. Invest. Atsuko Asahi, et al. 118:2939 doi:10.1172/JCI34496 [Go to this article.]

Figure 3
Serial measurements of immunologic and platelet turnover parameters before and after the H. pylori eradication in 14 H. pylori–positive ITP responders, 9 H. pylori–positive ITP nonresponders, and 11 H. pylori–negative ITP nonresponders. Anti-GPIIb/IIIa Ab–producing B cells, platelet-associated anti-GPIIb/IIIa Abs, GPIIb/IIIa-specific T cell response, tetanus toxoid–specific T cell response, proportion of reticulated platelets, circulating TPO level, expression levels of FcγRI and FcγRII (FcγRIIA plus FcγRIIB) on monocytes, proportion of FcγRIII-positive monocytes, expression level of CD86 on monocytes, nonspecific phagocytosis of circulating monocytes, and anti-CagA Ab levels were measured prior to treatment and 12 and 24 wk after initiation of the H. pylori eradication regimen. Expression of FcγRII was examined using mAb clone FLI8.26, which reacts with both FcγRIIA and FcγRIIB. Results are shown as the mean + SD. Changes in the values at 12 and 24 wk from the baseline value measured at wk 0 were assessed by paired t test. Dotted lines indicate the cut-off values: 2.0 for anti-GPIIb/IIIa Ab–producing B cells; 3.3 U for platelet-associated anti-GPIIb/IIIa Abs; 2.0% for % RP; and 7.5 U for anti-CagA Ab. ^†P < 0.1, *P < 0.05, and **P < 0.01 compared with wk 0.