Helicobacter pylori eradication shifts monocyte Fcγ receptor balance toward inhibitory FcγRIIB in immune thrombocytopenic purpura patients
J. Clin. Invest. Atsuko Asahi, et al. 118:2939 doi:10.1172/JCI34496 [Go to this article.]

Figure 1
Immunologic and platelet turnover parameters prior to treatment in ITP patients with or without H. pylori infection. The anti-GPIIb/IIIa Ab–producing B cells, platelet-associated (PA) anti-GPIIb/IIIa Abs, GPIIb/IIIa-specific T cell response, tetanus toxoid–specific (TT-specific) T cell response, proportion of reticulated platelets (%RP), circulating TPO level, expression levels of FcγRI and FcγRII (FcγRIIA plus FcγRIIB) on monocytes, proportion of FcγRIII-positive monocytes, expression level of CD86 on monocytes, and nonspecific phagocytosis of monocytes were compared among 23 ITP patients infected with H. pylori and 11 ITP patients who were not infected with H. pylori. Expression of FcγRII was examined using mAb clone FLI8.26, which reacts with both FcγRIIA and FcγRIIB. The differences between the 2 groups were analyzed using the Mann-Whitney U test.