Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice
J. Clin. Invest. Min-Jong Kang, et al. 118:2771 doi:10.1172/JCI32709 [
Go to this article.]
Figure 5Roles of IL-18Rα and IFN-γ in CS plus poly(I:C)–induced cytokine stimulation. WT (+/+) mice and mice with null mutations (–/–) of IL-18Rα or IFN-γ were exposed to CS or RA (CS–) for 2 weeks and then given 1 (
A and
B) or 4 doses (
C) of poly(I:C) (50 μg) or vehicle control. BAL IL-18 (
A), IL-12/IL-23 p40 (
B), and IFN-γ (
C) levels were quantitated. The noted values represent the mean ± SEM of evaluations in a minimum of 5 mice. *
P < 0.05; **
P < 0.01; ***
P < 0.001. ND, none detected.
