Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice
J. Clin. Invest. Min-Jong Kang, et al. 118:2771 doi:10.1172/JCI32709 [Go to this article.]

Figure 4
Roles of IL-18Rα and IFN-γ in the interaction of CS and poly(I:C). WT (+/+) mice and mice with null mutations (–/–) of IL-18Rα or IFN-γ were exposed to CS or RA (CS–) for 2 weeks and then given 4 doses of poly(I:C) (50 μg) or vehicle control. BAL total cell recovery (A), BAL differential cell recovery (B), and emphysema (C) were evaluated. The noted values represent the mean ± SEM of evaluations in a minimum of 5 mice. *P < 0.05; **P < 0.01.