Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice
J. Clin. Invest. Min-Jong Kang, et al. 118:2771 doi:10.1172/JCI32709 [
Go to this article.]
Figure 2Effects of poly(I:C) and other innate immunity agonists on mice exposed to RA or CS. Mice were exposed to CS or RA for 2 weeks and then randomized to receive 4 doses of poly(I:C) (50 μg), LPS (1–10 μg), GDQ (5–50 μg), or vehicle controls. The alterations in alveolar structure, alveolar chord length, and lung volume caused by poly(I:C) are noted in parts
A,
B, and
C. The effects of these interventions on matrix accumulation were assessed with trichrome evaluations (
D). The effects of LPS and GDQ on BAL inflammation are seen in
E and
F. The effects of LPS and GDQ on alveolar remodeling are illustrated in parts
G and
H, respectively. The values in
B,
C, and
E–
H represent the mean ± SEM of evaluations in a minimum of 5 mice. Parts
A and
C are representative of a minimum of 4 similar experiments. *
P < 0.05; **
P < 0.01. Original magnification, ×4 (
A); ×20 (
D).
