Cigarette smoke selectively enhances viral PAMP– and virus-induced pulmonary innate immune and remodeling responses in mice
J. Clin. Invest. Min-Jong Kang, et al. 118:2771 doi:10.1172/JCI32709 [
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Figure 1Inflammatory effects of poly(I:C) in mice exposed to RA or CS. C57BL/6J mice were exposed to CS or RA (NS, nonsmoking) for 2 weeks and then randomized to receive 4 doses of poly(I:C) [pIC+] or vehicle control [pIC–]. The effects of 4 doses of varying concentrations of poly(I:C) on BAL total cell recovery (
A), 4 doses of poly(I:C) (50 μg) on parenchymal (
B) and airway (
C) inflammation, and BAL differential cell recovery (
D) are illustrated. (
E) Effects of 4 doses of poly(I:C) on BALB/c mice breathing RA (CS–) and mice exposed to CS (CS+) are illustrated. (
F) Dose dependence of these inflammatory events in C57BL/6J mice. The values in parts
A,
D,
E, and
F represent the mean ± SEM of evaluations in a minimum of 5 mice. Parts
B and
C are representative of a minimum of 4 similar experiments. *
P < 0.05; **
P < 0.01; ***
P < 0.001. Original magnification, ×20.
